Rothoerl, Ralf Dirk and Schebesch, Karl-Michael and Kubitza, Marion and Woertgen, Chris and Brawanski, Alexander and Pina, Ana-Luisa (2006) ICAM-1 and VCAM-1 expression following aneurysmal subarachnoid hemorrhage and their possible role in the pathophysiology of subsequent ischemic deficits. CEREBROVASCULAR DISEASES, 22 (2-3). pp. 143-149. ISSN 1015-9770,
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Background: The pathophysiology of ischemic cerebral lesions following aneurysmal subarachnoid hemorrhage ( SAH) is poorly understood. There is growing evidence that inflammatory reactions could be involved in the pathogenesis of such delayed occurring ischemic lesions. The aim of this study was to evaluate adhesion molecules with regard to these lesions following SAH. Methods: Serum and cerebrospinal fluid ( CSF) samples were taken daily from 15 patients up to day 9 after SAH and evaluated for intercellular adhesion molecule-1 ( ICAM-1) and vascular adhesion molecule- 1 ( VCAM- 1). Results: CSF and serum samples correlated well during nearly the whole time course ( p < 0.0001). A secondary increase in ICAM-1 and VCAM- 1 in the serum and CSF correlated with an increase in flow velocity in the transcranial Doppler ( p > 0.0001 and p < 0.007) but not to a delayed lesion in the CT scan. Conclusion: We believe that inflammatory processes are involved in the pathogenesis of cerebral vasospasm but they might only be a part of a multifactorial pathogenesis. Copyright (c) 2006 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERCELLULAR-ADHESION MOLECULE-1; CEREBRAL VASOSPASM; CULTURED ENDOTHELIUM; GRANULOCYTE ADHESION; MONOCLONAL-ANTIBODY; CEREBROSPINAL-FLUID; ARTERIAL-WALL; E-SELECTIN; RATS; INFLAMMATION; adhesion molecules; intercellular adhesion molecule-1; vascular cell adhesion molecule-1; subarachnoid hemorrhage; vasospasm; ischemic neurological deficit, delayed |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 10:10 |
| Last Modified: | 01 Mar 2021 10:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35097 |
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