Gehrig, A. and Janssen, A. and Horling, F. and Grimm, C. and Weber, Bernhard H. F. (2006) The role of caspases in photoreceptor cell death of the retinoschisin-deficient mouse. CYTOGENETIC AND GENOME RESEARCH, 115 (1). pp. 35-44. ISSN 1424-8581, 1424-859X
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Early schisis cavities in the retinal bipolar cell layer accompanied by progressive loss of cone and rod photoreceptor cells are the hallmark of the retinoschisin-deficient (Rs1h(-/Y)) murine retina. With this study we aimed at elucidating the molecular events underlying the photoreceptor cell death in this established murine model of X-linked juvenile retinoschisis. We show that photoreceptor degeneration in the Rs1h(-/Y) mouse is due to apoptotic events peaking around postnatal day 18. Cell death is accompanied by increased expression of initiator and inflammatory caspases but not by downstream effector caspases. The strong induction of caspase-1 (Casp1) prompted us to explore its involvement in the apoptotic process. We therefore generated double knock-out mice deficient for both retinoschisin and Casp1. No direct influence of the Casp1 genotype on apoptosis could be identified although striking differences in the overall number of resident microglia were observed independent of the Rs1h genotype.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | X-LINKED RETINOSCHISIS; CYTOCHROME-C RELEASE; APOPTOSIS IN-VIVO; RETINAL DEGENERATION; NERVOUS-SYSTEM; JUVENILE RETINOSCHISIS; SIGNALING COMPLEX; MICE DEFICIENT; ENDONUCLEASE-G; IMMUNE-SYSTEM; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 11:11 |
| Last Modified: | 01 Mar 2021 11:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35113 |
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