Bregenzer, Nicole and Schaeffler, Andreas and Gelbmann, Cornelia M. and Steinkamp, M. and Reinshagen, M. and Schoelmerich, Juergen and Andus, T. (2006) Lack of correlation between the vitamin D receptor FokI start codon polymorphism and bone mineral density in patients with Crohn's disease. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 114 (1). pp. 1-5. ISSN 0947-7349,
Full text not available from this repository. (Request a copy)Abstract
Introduction: We have examined the association of bone mineral density of patients with inflammatory bowel disease with a polymorphism in the gene encoding the vitamin D receptor. The thymine/cytosine (T/C) polymorphism in the first of two start codons can be defined by a restriction fragment length polymorphism using the restriction endonuclease Fokl. Vitamin D receptor alleles containing the polymorphism have been denoted by f and alleles lacking the site by F. Methods: We report on an association analysis of a basic population of 244 caucasian patients with Crohn's disease. We have genotyped the Fold polymorphism of the VDR in these patients and associated the genotype with the bone mineral density of the lumbar spine and the femoral neck. Results: In the cohort 42% of the patients were scored FF homozygous, 43.7% Ff heterozygous, and 14.3% ff homozygous. 14.4% of the FF patients, 18.8% of the Ff patients, and 9.7% of the ff patients had osteoporosis of the lumbar spine and 21.25% of the FF patients, 25.3% of the Ff patients, and 18.5% of the ff patients had osteoporosis of the femoral neck. In this cohort no association between the genotype and the bone mineral density in the group as a whole nor when separated according to sex or age was found. Conclusions: In summary in our cohort no association of the Fokl polymorphism and the BMD of the lumbar spine and femoral neck in patients with inflammatory bowel disease was found.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; TRANSLATION INITIATION SITE; ULCERATIVE-COLITIS; FRENCH WOMEN; GENE; CALCIUM; OSTEOPOROSIS; ALLELES; FokI; inflammatory bowel disease; osteoporosis; vitamin D receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 13:39 |
| Last Modified: | 01 Mar 2021 13:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35150 |
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