Winner, Beate and Geyer, Martin and Couillard-Despres, Sebastien and Aigner, Robert and Bogdahn, Ulrich and Aigner, Ludwig and Kuhnert, Georg and Winkler, Juergen (2006) Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb. EXPERIMENTAL NEUROLOGY, 197 (1). pp. 113-121. ISSN 0014-4886, 1090-2430
Full text not available from this repository. (Request a copy)Abstract
Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/olfactory bulb system as well as in the hippocampus. Here, we study the impact of 6-hydroxydopamine (6-OHDA) lesions to the medial forebrain bundle on proliferation and neuronal differentiation of newly generated cells in the SVZ/olfactory bulb axis in adult rats. Proliferation in the SVZ decreased significantly after dopaminergic deafferentation. However, the number of neural progenitor cells expressing the proneuronal cell fate determinant Pax-6 increased in the SVZ. Survival and quantitative cell fate analysis of newly generated cells revealed that 6-OHDA lesions induced opposite effects in the two different regions of neurogenesis in the olfactory bulb: a transient decrease in the granule cell layer contrasts to a sustained increase of newly generated neurons in the glomerular layer. These data point towards a shift in the ratio of newly generated interneurons ill the olfactory bulb layers. Dopaminergic neurogenesis in the glomerular layer tripled after lesioning and consistent with this finding, the total number of tyrosine hydroxylase (TH)-positive cells increased. Thus, loss of dopaminergic input to the SVZ led to a distinct cell fate decision towards stimulation of dopaminergic neurogenesis in the olfactory bulb glomerular layer. This Study Supports the accumulating evidence that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons. (c) 2005 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARKINSONS-DISEASE; SUBVENTRICULAR ZONE; CELL-DEATH; RAT-BRAIN; DENTATE GYRUS; HIPPOCAMPAL NEUROGENESIS; SUBSTANTIA-NIGRA; ANIMAL-MODELS; NEURONS; PROLIFERATION; Parkinson disease; lesion; adult neurogenesis; neural progenitor/stem cell; BrdU; TH; Pax-6; cell fate; 6-OHDA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 13:38 |
| Last Modified: | 01 Mar 2021 13:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35152 |
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