Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma

Hartmann, A and Junker, K and Dietmaier, W and Schroder, S and Lopez, D and Hofstadter, F and Blaszyk, Hagen (2006) Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. HUMAN PATHOLOGY, 37 (1). pp. 117-120. ISSN 0046-8177, 1532-8392

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Abstract

Nephrogenic metaplasia or nephrogenic adenoma of the urinary tract may present a diagnostic challenge in surgical pathology practice. Previous case reports suggest the possibility of nephrogenic metaplasia progressing to clear cell adenocarcinoma, but a malignant potential of nephrogenic metaplasia. is generally not acknowledged. A case of a 70-year-old female patient with multiple recurrences of nephrogenic metaplasia of the urinary bladder and Subsequent development of clear cell adenocarcinoma is described. Immunohistochemical studies help to differentiate the 2 entities. Results of molecular Studies, particularly comparative genomic hybridization analysis. suggest clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in this case. (c) 2006 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: TRACT; ADENOMA; URETHRA; urinary bladder; clear cell carcinoma; nephrogenic metaplasia
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Pathologie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 01 Mar 2021 13:54
Last Modified: 01 Mar 2021 13:54
URI: https://pred.uni-regensburg.de/id/eprint/35166

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