Bregenzer, Nicole and Hartmann, Alexander and Strauch, Ulrike and Schoelmerich, Juergen and Andus, Tilo and Bollheimer, L. Cornelius (2006) Increased insulin resistance and beta cell activity in patients with Crohn's disease. INFLAMMATORY BOWEL DISEASES, 12 (1). pp. 53-56. ISSN 1078-0998,
Full text not available from this repository. (Request a copy)Abstract
Background: Pancreatitis and exocrine pancreatitic insufficiency have been described as extraintestinal manifestations of inflammatory bowel disease. In this study, we investigated whether the endocrine pancreatic function is also disturbed in patients with inflammatory bowel disease. Methods: Seventeen patients with Crohn's disease and 13 healthy volunteers participated in the study. We analyzed the plasma insulin response in a 75-g oral glucose tolerance test. Glucose and insulin levels were determined at time 0 (fasting levels) and 30, 60, 90, 120, 180, 240, and 300 min after glucose uptake. Insulin resistance and P cell function (BCF) were analyzed by calculating respective indices. Results: Fasting and oral glucose-tolerance test glucose levels appeared to be similar in patients with Crohn's disease and in the controls. Impaired fasting glucose, impaired glucose tolerance, and/or overt diabetes mellitus were not observed in the volunteers. Insulin as well as the index for BCF were significantly increased in patients with Crohn's disease. In addition, insulin resistance was shown to be significantly elevated in Crohn's disease. Conclusions: Patients with Crohn's disease reveal an increased insulin secretion caused by an enhanced BCF, which may be induced by an up-regulated enteropancreatic axis. This hypersecretion may override the insulin resistance given by the chronic inflammatory state.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY BOWEL-DISEASE; PANCREATIC FUNCTION; SECRETION; GLUCOSE; Crohn's disease; endocrine pancreas function; oral glucose tolerance test |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2021 14:00 |
| Last Modified: | 01 Mar 2021 14:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35172 |
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