Runza, VL and Hehlgans, Thomas and Echtenacher, Bernd and Zahringer, U and Schwaeble, Wilhelm J. and Maennel, Daniela N. (2006) Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages. JOURNAL OF ENDOTOXIN RESEARCH, 12 (2). pp. 120-126. ISSN 0968-0519,
Full text not available from this repository. (Request a copy)Abstract
Ficolins are pattern-recognition molecules of the innate immune system able to trigger the lectin pathway of the complement activation upon binding to microbial surfaces. In humans, two plasma ficolins have been identified and characterized, whereas a third cell-associated ficolin (M-ficolin) was found on monocyte surfaces. The mouse homologue of M-ficolin is called ficolin B. Although the spatial-temporal expression patterns of mouse ficolins have been described recently, the subcellular localization of ficolin B protein is so far unknown. By using ficolin B-specific antibodies and confocal microscopy, we show that ficolin B is expressed within mouse peritoneal exudate macrophages and is co-localized with Lamp-1, a marker for lysosomes and late endosomes. In addition, the data indicate that ficolin B expression is up-regulated upon macrophage activation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMPLEMENT PATHWAY; HAKATA ANTIGEN; ACTINOBACILLUS-PLEUROPNEUMONIAE; BINDING PROTEIN; IMMUNE-SYSTEM; CLONING; GENE; COLLECTINS; RECEPTORS; complement; endosomes; infection; lectin pathway |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Mar 2021 09:18 |
| Last Modified: | 02 Mar 2021 09:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35191 |
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