Walitza, Susanne and Renner, T. and Romanos, M. and Mecklinger, L. and Tucha, Oliver and Gerlach, M. and Lange, Klaus W. (2006) Genetic and neuroimaging studies in attention deficit hyperactivity disorder. NERVENHEILKUNDE, 25 (6). 421-+. ISSN 0722-1541,
Full text not available from this repository. (Request a copy)Abstract
Formal genetic and molecular genetic studies indicate that attention deficit hyperactivity disorder (ADHD) is highly heritable, involving multiple genes of moderate effect. Four genome-wide linkage studies and the most frequently reported positive results of association studies are reviewed. Linkage studies have detected chromosome 5p13 as a relevant region, which is in the vicinity of the location of the dopamine transporter gene (DAT1). The most frequently replicated findings in the candidate gene approach refer to polymorphisms in dopominergic (DRD4, DAT1) and serotonergic genes (SERT). Neuroimaging studies show that AND involves structural brain abnormalities in fronto-striatal regions, other cortical regions and the cerebellum. Functional neuroimaging have implicated dysfunction of the fronto-striatal circuitry as likely contributing to the pothophysiology of ADHD. The dopamine transporter is a key regulator of dopamine, In vivo neuroreceptor imaging has shown increased dopamine transporter binding in AND and a decrease following methylphenidate treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRYPTOPHAN HYDROXYLASE-2 GENE; FUNCTIONAL MAGNETIC-RESONANCE; DOPAMINE TRANSPORTER DENSITY; CEREBRAL GLUCOSE-METABOLISM; DEFICIT/HYPERACTIVITY DISORDER; BASAL GANGLIA; NEUROPSYCHOLOGICAL FUNCTION; HYPERKINETIC-DISORDER; RESPONSE-INHIBITION; BRAIN METABOLISM; attention deficit hyperactivity disorder; ADHD; genetics; neuroimaging |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Mar 2021 07:55 |
| Last Modified: | 03 Mar 2021 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35234 |
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