Cutolo, Maurizio and Straub, Rainer H. (2006) Stress as a risk factor in the pathogenesis of rheumatoid arthritis. NEUROIMMUNOMODULATION, 13 (5-6). pp. 277-282. ISSN 1021-7401, 1423-0216
Full text not available from this repository. (Request a copy)Abstract
Stress is now recognized as an important risk factor in the pathogenesis of autoimmune rheumatic diseases (i.e. rheumatoid arthritis) by considering that the activation of the stress response system influences the close relationships existing between the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and the immune system. The stress response results in the release of neurotransmitters (norepinephrine), hormones ( cortisol) and immune cells which serve to send an efferent message from the brain to the periphery. Major life events lead to an intense release of stress mediators (large time integral of released neurotransmitters and hormones), whereas in minor life events, only short-lived surges of neurotransmitters and hormones are expected. Therefore, it is suggested that neurotransmitters such as norepinephrine or stress hormones such as cortisol might have different effects on immune/inflammatory responses at high and low concentrations present during short or extended periods of time, respectively. Long-lasting ( chronic) stress may lead to proinflammatory effects because no adequate long-term responses of stress axes (antiinflammatory) are to be expected. Copyright (c) 2006 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; ADRENERGIC-RECEPTORS; INTERPERSONAL STRESS; CIRCADIAN-RHYTHMS; SYNOVIAL TISSUE; NERVE-FIBERS; IN-VITRO; GLUCOCORTICOIDS; DISEASES; HORMONES; stress; stress response system; autoimmune rheumatic diseases; cortisol; norepinephrine; rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Mar 2021 09:38 |
| Last Modified: | 03 Mar 2021 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35240 |
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