Bock, Joergen and Doenitz, Anna and Andreesen, Reinhard and Reichle, Albrecht and Hennemann, Burkhard (2006) Pericarditis after high-dose chemotherapy: More frequent than expected? ONKOLOGIE, 29 (7). pp. 321-324. ISSN 0378-584X,
Full text not available from this repository. (Request a copy)Abstract
Background: Pericarditis is a rare side-effect of chemotherapy and has been reported following administration of cyclophosphamide, doxorubicin and other drugs but not treosulfan. Case Reports: We report on 2 patients with retrosternal chest pain and typical widespread upward concave ST-segment elevation in the 12-lead electrocardiogram prompting the diagnosis of acute pericarditis. The patients had received treatment for multiple myeloma or relapsed mantle cell lymphoma with high-dose treosulfan alone or in combination with etoposide and carboplatin followed by autologous stem cell transplantation 5 days before onset of the symptoms. In both patients, no serological evidence of viral infection was found. Serum creatine kinase and serum cardiac troponin I remained unchanged. Within 24 h of onset of the symptoms, C-reactive protein increased from normal values (< 5 mg/l) to 95 mg/l and 115 mg/l, respectively. In one of the patients, a paroxysmal supraventricular arrhythmia occurred that persisted for 2 days. After treatment with diclofenac, both patients recovered completely within 1 week. Conclusion: The differential diagnosis of chest pain in the setting of high-dose chemotherapy with e.g. treosulfan should include pericarditis. The pathogenesis remains unclear. Alongside infections, direct toxic or immunological drug-related mechanisms are suggested.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; TREOSULFAN; COMPLICATIONS; COMBINATION; ESCALATION; REGIMEN; CANCER; TRIAL; treosulfan; pericarditis; chemotherapy; side effects |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Mar 2021 08:38 |
| Last Modified: | 03 Mar 2021 08:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35250 |
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