Kelber, O. and Wittwer, A. and Lapke, C. and Kroll, U. and Weiser, D. and Okpanyi, S. N. and Heilmann, Joerg (2006) Ex vivo/in vitro absorption of STW 5 (Iberogast (R)) and its extract components. PHYTOMEDICINE, 13. pp. 107-113. ISSN 0944-7113,
Full text not available from this repository. (Request a copy)Abstract
To correlate the pharmacological effects of the fixed herbal combination STW 5 (Iberogas (R)) containing nine extract components with its confirmed clinical efficacy, ex vivo/in vitro absorption tests were performed. For the investigation, the everted gut sac technique and, in a pilot study, the Caco-2-cell model were used. The absorption rate of the extracts was determined by measuring characteristic marker substances of each of the individual extracts using HPLC or GC techniques. The results allow us to conclude that the investigated substances from STW 5 possess a good bioavailability, which is in accordance with the rapid onset of the therapeutic efficacy and explains its known pharmacological effects and clinical efficacy in terms Of multiple drug action and multi-target therapy, respectively. (c) 2006 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; CACO-2 MONOLAYERS; GLYCYRRHETIC ACID; ROSMARINIC ACID; METABOLISM; TRANSPORT; RATS; PHARMACOKINETICS; DISPOSITION; INTESTINE; ex vivo/in vitro absorption studies; everted gut sac; Caco-2; STW 5 (Iberogast (R)); Iberis amara; Matricaria recutita; Carum carvi; Silybum marianum; Melissa officinaliy; Mentha piperita; Chelidonium majus; Glycyrhiza glabra; Glucoiberin; Cucurbitacine E; chelidonic acid |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Mar 2021 10:29 |
| Last Modified: | 03 Mar 2021 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35267 |
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