Kasper, G and Weiser, AA and Rump, A and Sparbier, K and Dahl, E and Hartmann, A and Wild, P and Schwidetzky, U and Castanos-Velez, E and Lehmann, K (2005) Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients. INTERNATIONAL JOURNAL OF CANCER, 117 (6). pp. 961-973. ISSN 0020-7136, 1097-0215
Full text not available from this repository. (Request a copy)Abstract
We investigated the expression pattern of the breast cancer associated gene LIV-1 on all and protein level in 111 human breast cancer patients by in situ hybridization as well as immunohistochemistry and focused on the unknown potential of LIV-1 expression levels as a prognostic marker. To our knowledge, this is the first study on endogenous LIV-1 protein expression. Results of our study indicate that LIV-1 mRNA and protein expression levels are only weakly correlated, suggesting posttranscriptional regulatory mechanisms. Furthermore, LIV-1 mRNA quantity in combination with a positive ER status seem to represent a better marker than the progesterone receptor status according to the prognostic significance for relapse free survival (RFS). A negative correlation of LIV-1 protein levels with tumor size, grade and stage reflects an association of LIV-1 protein expression with less aggressive tumors. High LIV-1 protein expression seems to be associated with a longer relapse free and overall survival in breast cancer patients with invasive ductal carcinoma. This association, however, seems to be dependent from other prognostic markers. Our data suggest that LIV-1 is a promising candidate for a novel marker for breast cancer patients with better outcome. Furthermore, our study presents a revised cDNA sequence of LIV-1 and demonstrates the localization of endogenous LIV-1 in the endoplasmic reticulum. (Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience. wiley.com/jpages/0020-7136/suppmat/index.html). (c) 2005 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESTROGEN-REGULATED GENES; MESSENGER-RNA; POSTTRANSLATIONAL MODIFICATIONS; PROGESTERONE-RECEPTOR; MICROARRAY ANALYSIS; PROTEIN; CELLS; METALLOTHIONEIN; RESISTANCE; CARCINOMA; survival; estrogen receptor; LIV-1; tamoxifen |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Mar 2021 10:01 |
| Last Modified: | 04 Mar 2021 10:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35311 |
Actions (login required)
 |
View Item |
