Wensel, Roland and Francis, D. P. and Georgiadou, P. and Scott, A. and Genth-Zotz, S. and Anker, Stefan D. and Coats, A. J. S. and Piepoli, M. F. (2005) Exercise hyperventilation in chronic heart failure is not caused by systemic lactic acidosis. EUROPEAN JOURNAL OF HEART FAILURE, 7 (7). pp. 1105-1111. ISSN 1388-9842,
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Background: Patients with heart failure have an abnormally high ventilatory response to exercise associated with gas exchange defects and reduced arterial PCO2. Aims: We examined the possibility of lactic acidosis as the stimulus to this increased ventilation that abnormally depresses pCO(2) during exercise in heart failure. Method and results: We studied 18 patients with chronic heart failure. We measured VE/VCO2 slope during exercise, arterial blood gases and lactate concentrations during cardiopulmonary exercise testing (rest, peak exercise and one minute after the end of exercise). Neither VE/VCO2 slope nor arterial pCO(2), were related to arterial lactate concentrations at peak exercise (r-0.16, p=0.65 and r=-0.15, p=0.6). During early recovery, patients with a high VE/VCO2 slope had a particularly pronounced rise in arterial lactate and hydrogen ion concentrations (r=0.57, P < 0.05 and r=0.84,p < 0.0001) and yet their arterial pCO(2) rose rather than fell (r=0.79, p < 0.001). The rise in arterial pCO(2) correlated with the increase in arterial hydrogen concentration (r=0.78, p < 0.001) and with arterial pCO(2) at peak exercise (r=-0.76, p < 0.001). Conclusions: In heart failure VE/VCO2 Slope and low arterial pCO2 at peak exercise are not related to the degree of systemic lactic acidosis. Lactic acidosis is therefore not a plausible mechanism of exercise induced hyperventilation. (c) 2004 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROUP-IV AFFERENTS; SKELETAL-MUSCLE; VENTILATORY RESPONSES; FUNCTIONAL-CAPACITY; ISOMETRIC-EXERCISE; GAS-EXCHANGE; GROUP-III; HUMANS; CHEMOSENSITIVITY; ACCUMULATION; heart failure; exercise; ventilation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Apr 2021 12:56 |
| Last Modified: | 12 Apr 2021 12:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35347 |
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