Stehr, Alexander and Ploner, Franz and Traeger, Karl and Theisen, Marc and Zuelke, Carl and Radermacher, Peter and Matejovic, Martin (2005) Plasma disappearance of indocyanine green: a marker for excretory liver function? INTENSIVE CARE MEDICINE, 31 (12). pp. 1719-1722. ISSN 0342-4642, 1432-1238
Full text not available from this repository. (Request a copy)Abstract
Objective: To investigate whether the plasma disappearance rate of indocyanine green (ICG) assessed using a commercially available bedside monitor provides an accurate estimation of cumulative biliary ICG excretion in a clinically relevant model of long-term, hyperdynamic porcine endotoxemia. Design and setting: Prospective experimental study in the animal laboratory in a university hospital. Subjects: Fifteen domestic pigs. Interventions: Pigs were anesthetized, mechanically ventilated, and instrumented. Intravenous endotoxin was continuously infused over 12 h concomitant with fluid resuscitation. Measurements were performed before and 12 h after the start of endotoxin infusion. Measurements and results: All animals developed hyperdynamic circulation characterized by a sustained increase in cardiac output. Despite well maintained portal venous and consequently total liver blood flow endotoxemia decreased hepatic lactate uptake, which was accompanied by a significant fall in portal and hepatic venous pH. Both the cumulative bile flow and biliary ICG and bicarbonate excretion measured during 1 h after intravenous bolus of 25 mg ICG fell significantly. By contrast, neither the plasma disappearance rate of ICG nor the rate corrected for liver blood flow exhibited any changes over time. Conclusions: In hyperdynamic porcine endotoxemia the plasma disappearance rate of ICG failed to accurately substitute for direct short-term measures of biliary ICG excretion. Hence normal values of plasma disappearance rate of ICG should be interpreted with caution in early, acute inflammatory conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATIC EXTRACTION RATIO; CRITICALLY-ILL PATIENTS; PORCINE ENDOTOXEMIA; ENERGY-METABOLISM; BLOOD-FLOW; PHARMACOKINETICS; NICOTINAMIDE; INHIBITOR; TRANSPORT; GUT; endotoxin; sepsis; indocyanine green; liver function; liver blood flow; biliary excretion |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Apr 2021 08:58 |
| Last Modified: | 14 Apr 2021 08:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35361 |
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