Nickel, Cerstin and Tritt, Karin and Muehlbacher, Moritz and Gil, Francisco Pedrosa and Mitterlehner, Ferdinand O. and Kaplan, Patrick and Lahmann, Claas and Leiberich, Peter K. and Krawczyk, Jakub and Kettler, Christian and Rother, Wolfhardt K. and Loew, Thomas H. and Nickel, Marius K. (2005) Topiramate treatment in bulimia nervosa patients: A randomized, double-blind, placebo-controlled trial. INTERNATIONAL JOURNAL OF EATING DISORDERS, 38 (4). pp. 295-300. ISSN 0276-3478, 1098-108X
Full text not available from this repository. (Request a copy)Abstract
Objective: The aim of the current study was to test the influence of topiramate on behavior, body weight, and health-related quality of life (HRQOL) in bulimic patients. Method: Thirty patients with bulimia nervosa were treated with topiramate in a 10-week randomized, double-blind, placebo-controlled study. The subjects were randomly assigned to receive topiramate (topiramate group [TG]; n = 30) or a placebo (control group [CG]; n = 30). Primary outcome measures were changes in the frequency of binging/purging, in body weight, and on the SF-36 Health Survey (SF-36) scales. Results: In comparison to the CG group (according to the intent-to-treat principle), significant changes in the frequency of binging/purging (a > 50% reduction: TG, n = 11 [36.7%]; CG, n = 1 [3.3%]; p <.001), body weight (difference in weight loss between the two groups: 3.8 kg, 95% confidence interval [CI] = -5.4 to -2.1; p <.001), and SF-36 (all ps <.001) could be seen. All patients tolerated topiramate well. Conclusion: Topiramate appears to safe and effective in influencing the frequency of binging/purging, body weight, and HRQOL in bulimic patients. (c) 2005 by Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINGE-EATING DISORDER; QUALITY-OF-LIFE; CASE SERIES; IMPROVEMENT; bulimia nervosa; topiramate; frequency of binging/purging; body weight; health-related quality of life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Apr 2021 09:07 |
| Last Modified: | 14 Apr 2021 09:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35363 |
Actions (login required)
 |
View Item |
