Obermann, Ellen C. and Went, P and Pehrs, AC and Tzankov, A and Wild, PJ and Pileri, S and Hofstaedter, Ferdinand and Dirnhofer, S (2005) Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. ONCOLOGY REPORTS, 14 (6). pp. 1461-1467. ISSN 1021-335X,
Full text not available from this repository. (Request a copy)Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most frequent non-Hodgkin's lymphoma in the Western world; it is characterized by marked genetic, morphological and clinical heterogeneity. The identification of prognostic markers could help to develop risk-adapted treatment strategies. As proliferation of cells is essential for tumour growth, analysis of the cell cycle and its individual phases might give additional information on tumour progression and clinical behaviour. To investigate the prognostic value of proteins specifically related to the cell cycle phases S, G2 and M in DLBCL, the expression of cyclin A as a marker of S phase and cyclin B I as a G2/M phase marker were analysed in combination with other clinico-pathological parameters in a large cohort of patients. Expression of cyclin B I and cyclin A were determined by immunohistochemistry using tissue microarray methodology. Immunoreactivity for cyclin B I and cyclin A was correlated with clinical data using a two-sided Fisher's exact test. Impact on overall survival was analysed by the Kaplan-Meier method. A negative prognostic impact was found for expression of cyclin B I. Nuclear and/or cytoplasmic staining in >= 1% of tumour cells was significantly associated with shorter overall survival in the multivariate analysis (P=0.008). Furthermore, the prognostic impact of cyclin B I expression was independent of the tumour stage. No prognostic significance was found for expression of cyclin A. In conclusion, this study demonstrates the independent prognostic value of an expression of cyclin B I in DLBCL and proposes its evaluation as a prognostic marker in the assessment of this entity which is easily applicable in daily routine practice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMAS; CYCLE PHASE DISTRIBUTION; IMMUNOHISTOCHEMICAL METHOD; PROLIFERATIVE ANTIGEN; FOLLICULAR LYMPHOMA; COLORECTAL-CANCER; DEPENDENT KINASE; DNA-REPLICATION; ONCOLOGY-GROUP; KI-67 PROTEIN; diffuse large B-cell lymphoma; cyclin B1; cyclin A; tissue microarray; immunohistochemistry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Apr 2021 11:33 |
| Last Modified: | 20 Apr 2021 11:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35387 |
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