Dietl, Barbara and Schaefer, D. and Koelbl, Oliver (2005) The prognostic value of time parameters in adjuvant radiotherapy of head and neck cancer. A retrospective analysis of 138 patients. STRAHLENTHERAPIE UND ONKOLOGIE, 181 (12). pp. 800-807. ISSN 0179-7158,
Full text not available from this repository. (Request a copy)Abstract
Purpose: To answer the question, how the parameters waiting time, radiation treatment time and overall treatment time (OTT) influenced the endpoints overall (OS), event-free (EFS) and Local recurrence-free survival (LRFS) in patients with locally advanced head-and-neck cancer, who had received postoperative radiotherapy. Patients and Methods: 138 patients were included into a retrospective analysis from 10/1993 to 05/2000. Besides the time parameters waiting time, radiation treatment time and OTT tumor- and therapy-related parameters (T-, N-, R-status, grading, tumor site, surgical technique, and postoperative hemoglobin < 12 g/dl) with potential impact on the endpoints were investigated in the univariate analysis (Kaplan-Meier log-rank test). Individual parameters with a significant impact (p = 0.05) were subjected to a multivariate Cox regression analysis. Results: Besides a postoperative hemoglobin value < 12 g/dl, in the univariate analysis an OTT >= 105 days negatively influenced all endpoints, as well as a radiation treatment time >= 60 days. On multivariate Cox regression analysis, postoperative hemoglobin < 12 g/dL and an OTT >= 105 days were identified as independent negative prognostic factors for all endpoints. Conclusion: The waiting time should be managed according to the ASARA (as short as reasonably achievable) recommendation, radiation treatment should not be protracted exceeding an overall treatment of 105 days. Generally, time parameters should be routinely included in the standard tumor documentation, thus facilitating further evaluation of these prognostically relevant factors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; POSTOPERATIVE RADIATION-THERAPY; UPPER AERODIGESTIVE TRACT; LOCALLY ADVANCED HEAD; LOCOREGIONAL CONTROL; ORAL-CAVITY; SURGERY; SURVIVAL; DELAY; TRIAL; time parameters; waiting time; radiation treatment time; treatment package time; head-and-neck cancer; prognostic factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2021 04:53 |
| Last Modified: | 23 Apr 2021 04:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35401 |
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