Wirth, Matthias and Mahboobi, Siavosh and Kraemer, Oliver H. and Schneider, Guenter (2016) Concepts to Target MYC in Pancreatic Cancer. MOLECULAR CANCER THERAPEUTICS, 15 (8). pp. 1792-1798. ISSN 1535-7163, 1538-8514
Full text not available from this repository. (Request a copy)Abstract
Current data suggest that MYC is an important signaling hub and driver in pancreatic ductal adenocarcinoma (PDAC), a tumor entity with a strikingly poor prognosis. No targeted therapies with a meaningful clinical impact were successfully developed against PDAC so far. This points to the need to establish novel concepts targeting the relevant drivers of PDAC, like KRAS or MYC. Here, we discuss recent developments of direct or indirect MYC inhibitors and their potential mode of action in PDAC. (C)2016 AACR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMALL-MOLECULE INHIBITORS; BET BROMODOMAIN INHIBITION; COVALENT CDK7 INHIBITOR; C-MYC; DUCTAL ADENOCARCINOMA; SELECTIVE-INHIBITION; PROTEIN-DEGRADATION; THERAPEUTIC TARGETS; UBIQUITIN LIGASE; FAMILY PROTEINS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Aug 2020 08:36 |
| Last Modified: | 28 Aug 2020 08:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3542 |
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