Boeger, Carsten A. and Fischereder, Michael and Deinzer, Martina and Aslanidis, Charalampos and Schmitz, Gerd and Stubanus, M. and Banas, Bernhard and Kruger, B. and Riegger, Guenter A. J. and Kramer, Bernhard K. (2005) RANTES gene polymorphisms redict all-cause and cardiac mortality in type 2 diabetes mellitus hemodialysis patients. ATHEROSCLEROSIS, 183 (1). pp. 121-129. ISSN 0021-9150,
Full text not available from this repository. (Request a copy)Abstract
Introduction: Patients with type 2 diabetes (DM2) and end stage renal disease (ESRD) have a dismal survival prognosis, mainly due to cardiovascular events. There is sparse data on genetic predictors. Chemokines and their receptors are important in regulating leukocyte influx and activation in atherosclerosis, and functional polymorphisms in the respective genes are associated with cardiovascular disease risk. Methods: We enrolled 225 prevalent Caucasian DM2 patients receiving maintenance hemodialysis in 30 centres in Southern Germany (time from dialysis initiation < 2.0 years) from August 1999 to January 2000 for prospective study until December 2003. The CX3CR1 T280M, and MCP-1 -2518 and RANTES -403 and -28 promoter and intronic In1.1T/C polymorphisms were assessed by real-time PCR. Primary end point was all-cause mortality (ACM). Results: Patients carrying the RANTES -403A or In1.1C allele had a significantly higher ACM risk (multivariate hazard ratio for -403A, dominant model = 1.81 [95% Cl: 1.22-2.671, p = 0.003), mainly due to cardiac events. Similar data were obtained by haplotype analysis. The other SNPs showed no effect on survival. Discussion: In DM2 patients with ESRD, ACM due to cardiac events is associated with RANTES gene variants that are known to alter the expression of this chemokine important in atherosclerosis. Further study of the role of chemokine and chemokine receptor gene variation in determining vascular end points is needed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCYTE CHEMOATTRACTANT PROTEIN-1; CHEMOKINE RECEPTOR-5; HIV-1 INFECTION; T-CELLS; PROMOTER; DISEASE; GENOTYPE; NEPHROPATHY; RECRUITMENT; ANTAGONIST; genetics of vascular disorders; atherosclerosis; dialysis; adult diabetes; cardiovascular risk |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2021 09:17 |
| Last Modified: | 23 Apr 2021 09:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35448 |
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