Cidlinsky, Natascha and Dogliotti, Giada and Pukrop, Tobias and Jung, Rudolf and Weber, Florian and Krahn, Michael P. (2016) Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report. CELLULAR ONCOLOGY, 39 (4). pp. 389-396. ISSN 2211-3428, 2211-3436
Full text not available from this repository. (Request a copy)Abstract
Activation of AMPK by the tumor suppressor LKB1 represents an essential gatekeeping step for cells under energetic stress to prevent their growth and proliferation by inhibiting mTOR activation, until the energy supply normalizes. The LKB1/AMPK pathway is frequently downregulated in various types of cancer, thereby uncoupling tumor cell growth and proliferation from energy supply. As yet, little information is available on the role of the LKB1/AMPK pathway in tumors derived from salivary gland tissues. We performed LKB1 protein expression and AMPK and mTOR activation analyses in several salivary gland tumor types and their respective healthy control tissues using immunohistochemistry. No significant downregulation of LKB1 expression or decreased activation of AMPK or mTOR were observed in any of the salivary gland tumors tested. In contrast, we found that the salivary gland tumors exhibited an increased rather than a decreased AMPK activation. Although the PI3K/Akt pathway was found to be activated in most of the analyzed tumor samples, the unchanged robust activity of LKB1/AMPK likely prevents (over)activation of mTOR. In contrast to many other types of cancer, inactivation or downregulation of the LKB1/AMPK pathway does not substantially contribute to the pathogenesis of salivary gland tumors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PEUTZ-JEGHERS-SYNDROME; SYNDROME KINASE LKB1; MAMMALIAN TARGET; CELL POLARITY; CANCER; MUTATIONS; MTOR; AMPK; LUNG; ADENOCARCINOMAS; LKB1; AMPK; mTOR; PI3K-pathway; Salivary gland tumor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Apr 2019 11:25 |
| Last Modified: | 05 Apr 2019 11:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3546 |
Actions (login required)
 |
View Item |
