Poeppl, Timm B. and Mueller, Veronika I. and Hoffstaedter, Felix and Bzdok, Danilo and Laird, Angela R. and Fox, Peter T. and Langguth, Berthold and Rupprecht, Rainer and Sorg, Christian and Riedl, Valentin and Goya-Maldonado, Roberto and Gruber, Oliver and Eickhoff, Simon B. (2016) Imbalance in Subregional Connectivity of the Right Temporoparietal Junction in Major Depression. HUMAN BRAIN MAPPING, 37 (8). pp. 2931-2942. ISSN 1065-9471, 1097-0193
Full text not available from this repository. (Request a copy)Abstract
Major depressive disorder (MDD) involves impairment in cognitive and interpersonal functioning. The right temporoparietal junction (RTPJ) is a key brain region subserving cognitive-attentional and social processes. Yet, findings on the involvement of the RTPJ in the pathophysiology of MDD have so far been controversial. Recent connectivity-based parcellation data revealed a topo-functional dualism within the RTPJ, linking its anterior and posterior part (aRTPJ/pRTPJ) to antagonistic brain networks for attentional and social processing, respectively. Comparing functional restingstate connectivity of the aRTPJ and pRTPJ in 72 MDD patients and 76 well-matched healthy controls, we found a seed (aRTPJ/pRTPJ) x diagnosis (MDD/controls) interaction in functional connectivity for eight regions. Employing meta-data from a large-scale neuroimaging database, functional characterization of these regions exhibiting differentially altered connectivity with the aRTPJ/pRTPJ revealed associations with cognitive (dorsolateral prefrontal cortex, parahippocampus) and behavioral (posterior medial frontal cortex) control, visuospatial processing (dorsal visual cortex), reward (subgenual anterior cingulate cortex, medial orbitofrontal cortex, posterior cingulate cortex), as well as memory retrieval and social cognition (precuneus). These findings suggest that an imbalance in connectivity of subregions, rather than disturbed connectivity of the RTPJ as a whole, characterizes the connectional disruption of the RTPJ in MDD. This imbalance may account for key symptoms of MDD in cognitive, emotional, and social domains. (C) 2016 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIRECT-CURRENT STIMULATION; SUPERIOR PARIETAL CORTEX; VOXEL-BASED MORPHOMETRY; SHAM-CONTROLLED TRIALS; SOCIAL COGNITION; FUNCTIONAL CONNECTIVITY; CYTOARCHITECTONIC AREAS; DOUBLE-BLIND; METAANALYSIS; DISORDER; major depressive disorder; depression; right temporoparietal junction; resting state; connectivity; functional magnetic resonance imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Apr 2019 11:28 |
| Last Modified: | 05 Apr 2019 11:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3548 |
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