Weigert, Johanna and Neumeier, Markus and Schaeffler, Andreas and Fleck, Martin and Schoelmerich, Juergen and Schuetz, Christian and Buechler, Christa (2005) The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells. FEBS LETTERS, 579 (25). pp. 5565-5570. ISSN 1873-3468,
Full text not available from this repository. (Request a copy)Abstract
The adiponectin paralog CORS-26 (collagenous repeat-containing sequence of 26 kDa protein) is a member of the C1q/TNF-alpha molecular superfamily. CORS-26 is a secreted protein and baculovirus-produced CORS-26 released in the supernatant of insect cells forms stable trimers. Adiponectin exerts anti-inflammatory effects in LPS-treated monocytic cells and CORS-26 also reduces IL-6 and TNF-alpha secretion but does not increase IL-10. Suppression of NF kappa B signalling may explain the anti-inflammatory actions of CORS-26. Furthermore CORS-26 protein was detected in human monocytic and dendritic cells. The present data demonstrate for the first time that CORS-26 forms trimers, exerts anti-inflammatory properties and that it is expressed in monocytic cells. Therefore CORS-26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN BLOOD MONOCYTES; PROTEIN; LIPOPROTEIN; EXPRESSION; GENE; adiponectin; macrophage; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 05:20 |
| Last Modified: | 26 Apr 2021 05:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35523 |
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