Chuang, W. Y. and Strobel, P. and Gold, R. and Nix, W and Schalke, Berthold and Kiefer, R. and Opitz, A. and Klinker, E. and Mueller-Hermelink, H. K. and Marx, Alexander (2005) A CTLA4(high) genotype is associated with myasthenia gravis in thymoma patients. ANNALS OF NEUROLOGY, 58 (4). pp. 644-648. ISSN 0364-5134, 1531-8249
Full text not available from this repository. (Request a copy)Abstract
Myasthenia gravis (MG) in thymoma patients depends critically on intraturnorous generation and export of mature autoreactive CD4(+) T cells. Why non-MG thymomas fail to produce CD4(+) T cells is unknown. We studied three single-nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4(CTLA4) gene in thymoma patients, nonthymoma early-onset MG patients, and control subjects. Surprisingly, the CTLA4(high) geno- type +49A/A, which is protective against several autoimmune diseases, exerted a prominent predisposing effect to paraneoplastic MG in thymoma patients. The unusual disease association with a CTLA4(high) genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4(+) T cells in MG-associated thymomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CTLA-4 GENE POLYMORPHISM; NEGATIVE SELECTION; T-CELLS; PROMOTER; DISEASE; EXPRESSION; SUSCEPTIBILITY; REGION; CD4(+); MATURE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 07:10 |
| Last Modified: | 26 Apr 2021 07:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35544 |
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