Wiezer, Arnim and Merkl, Rainer (2005) A comparative categorization of gene flux in diverse microbial species. GENOMICS, 86 (4). pp. 462-475. ISSN 0888-7543, 1089-8646
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Microbial genomes harbor genomic islands (GIs), genes presumably acquired via horizontal gene transfer (HGT). We compared GIs of hyperthermophilic, thermophilic, mesophilic, and pathogenic/nonpathogenic species and of small and large genomes. The COG database was used to characterize gene-encoded functions. Putative donors were determined to quantify gene flux between superkingdoms. In hyperthermophiles, more than 10% of the genes were on average acquired across the superkingdom border. For thermophiles and particularly mesophiles, we identified a nearly unidirectional export from bacteria to archaea. Additionally, we analyzed GI composition for Escherichia, and pairs of Listeria, Rhizobiales, Methanosarcinaceae, and Thermus thermophilus/Deinococcus radiodurans. For Escherichia and Listeria, the composition of GIs in pathogenic and nonpathogenic species did not differ significantly with respect to encoded COG classes. The analysis of related genomes showed that the composition of GIs cannot be explained with trends of gene content known to depend on genome size. (C) 2005 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THERMOPHILE THERMUS-THERMOPHILUS; COMPLETE GENOME SEQUENCE; ESCHERICHIA-COLI; PATHOGENICITY ISLANDS; BACTERIAL GENOMES; THERMOTOGA-MARITIMA; TRANSFERRED GENES; PROTEIN FAMILIES; ARCHAEAL GENES; EVOLUTION; horizontal gene transfer; lateral gene transfer; gene flux; COG database; genomic islands; xenologous genes |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 08:52 |
| Last Modified: | 26 Apr 2021 08:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35567 |
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