Schweda, Frank and Segerer, Florian and Castrop, Hayo and Schnermann, Juergen and Kurtz, Armin (2005) Blood pressure-dependent inhibition of renin secretion requires A1 adenosine receptors. HYPERTENSION, 46 (4). pp. 780-786. ISSN 0194-911X,
Full text not available from this repository. (Request a copy)Abstract
Renal perfusion pressure (RPP) regulates renin release with a reduction of RPP stimulating and an elevation inhibitin renin secretion. The precise sensing and effector mechanisms by which changes in arterial pressure are linked to the exocytosis of renin are not well-defined. The present experiments were designed to study the potential role of adenosine as a mediator of this renal baroreceptor mechanism. In isolated perfused mouse kidneys a stepwise reduction of RPP from 90 rum Hg to 65 and 40 mm Hg stimulated renin secretion rates (RSR) 1.4-fold and 3.6-fold, whereas stepwise elevations of RPP from 90 mm Hg to 115 and 140mm Hg suppressed RSR to 64% or 40% of baseline. Inactivation of A1 adenosine receptors by either pharmacological blockade (DPCPX 1 mu mol/L) or genetic deletion (A1AR(-/-) mice) did not modify the stimulation of renin release by a low RPP, but completely prevented the suppression of renin secretion by higher perfusion pressures. In vivo, the induction of arterial hypertension by either acute (single subcutaneous injection) or chronic (osmotic minipump for 72 hours) application of phenylephrine significantly reduced plasma renin concentration (PRC) in wild-type mice to approximate to 40% of control, whereas it did not significantly affect PRC in A1AR(-/-) mice. Together these data demonstrate that A1 adenosine receptors are indispensable for the inhibition of renin secretion by an increase in blood pressure, suggesting that formation and action of adenosine is responsible for baroreceptor-mediated inhibition of renin release. In contrast, the stimulation of the renin system by a low blood pressure appears to follow different pathways.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENOVASCULAR HYPERTENSION; TUBULOGLOMERULAR FEEDBACK; GENE-EXPRESSION; JUXTAGLOMERULAR CELLS; PLASMA-RENIN; MICE LACKING; MACULA DENSA; RAT-KIDNEY; CLIP RATS; RELEASE; kidney; phenylephrine; prostaglandins |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 09:07 |
| Last Modified: | 26 Apr 2021 09:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35579 |
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