Straub, Rainer H. and Haerle, Peter and Kriegel, M. and Schoelmerich, Juergen and Lorenz, H. M. (2005) Adrenal and gonadal hormone variations during a febrile attack in a woman with tumor necrosis factor receptor-associated periodic syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 90 (10). pp. 5884-5887. ISSN 0021-972X,
Full text not available from this repository. (Request a copy)Abstract
Context: TNF-receptor-associated periodic syndrome (TRAPS) is a hereditary fever syndrome that results from mutations in the TNF-receptor superfamily 1A gene (TNFRSF1A). It is characterized by periodic fever, arthralgia, abdominal pain, myalgia, headache, and skin lesions. Objective: Because adrenal and gonadal hormone cascades are modulated by TNF, this study aimed to investigate specific hormones and enzyme steps during an attack phase in a woman with TRAPS. Design: Morning blood samples were taken from a 38-yr-old woman before, during, and after the febrile episode in the late luteal, menstrual, and early follicular phase of the menstrual cycle, respectively. Results: Serum cortisol levels were markedly increased throughout the entire observation period and demonstrated a dip during the attack phase. In contrast, serum levels of dehydroepiandrosterone and 17-hydroxyprogesterone demonstrated a sharp rise during the febrile episode. Dehydroepiandrosterone in relation to androstenedione or cortisol was increased. Indicative of aromatase activation, estrone and 17 beta-estradiol demonstrated a marked increase during the attack phase. Conclusion: This study suggests that some important steroid hormone-conversion steps are activated (aromatase) and inhibited (second step of the P450c17 and the 3 beta-hydroxysteroid dehydrogenase) during the inflammatory attack phase in a TRAPS patient. These changes of enzyme pathways are typical on the basis of increased TNF signaling.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADIPOSE STROMAL CELLS; RHEUMATOID-ARTHRITIS; FACTOR-ALPHA; AROMATASE EXPRESSION; GENE-EXPRESSION; SYNOVIAL-FLUID; IN-VITRO; INTERLEUKIN-6; ESTROGEN; DEHYDROEPIANDROSTERONE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 10:13 |
| Last Modified: | 26 Apr 2021 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35590 |
Actions (login required)
 |
View Item |
