Leinisch, Elke and Evers, S. and Kaempfe, N. and Kraemer, C. and Sostak, P. and Juergens, T. and Straube, A. and May, Arne (2005) Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study. PAIN, 117 (3). pp. 396-400. ISSN 0304-3959, 1872-6623
Full text not available from this repository. (Request a copy)Abstract
The efficacy of intravenous acetaminophen (1000 mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to the International Headache Society Classification. Sixty patients were included in three headache outpatient centers (Neurology Departments of the Universities of Regensburg, Munster and Munchen). In the acute migraine attack patients were treated intravenously with either 1000 mg paracetamol (acetaminophen) or placebo. The primary end point was pain-free after 2 h. Secondary efficacy criteria were pain-free after 24 h or pain relief after 2 hours and after 24 hours. With regard to the efficacy criteria, 37% of patients reported pain relief or painfree after two hours, 12 patients after treatment with acetaminophen and 10 patients after treatment with placebo. Out of these, 3 patients in the acetaminophen and 4 patients in the placebo group were painfree. After 24 hours 86% of the patients reported pain relief: 24 treated with acetaminophen and 27 treated with placebo. The results indicate, that 1000 mg intravenous acetaminophen is not superior to placebo in treating severe acute migraine attacks. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACETYLSALICYLIC-ACID; ANALGESIC EFFICACY; CLUSTER HEADACHE; CLINICAL-TRIALS; PARACETAMOL; SAFETY; SUMATRIPTAN; MANAGEMENT; MEDICATION; IBUPROFEN; migraine; acetaminophen; parenteral; acute treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2021 12:28 |
| Last Modified: | 26 Apr 2021 12:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35609 |
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