Neumeier, Markus and Weigert, Johanna and Schaeffler, Andreas and Weiss, Thomas and Kirchner, Stefan and Laberer, Sabine and Schoelmerich, Juergen and Buechler, Christa (2005) Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334 (3). pp. 924-929. ISSN 0006-291X, 1090-2104
Full text not available from this repository. (Request a copy)Abstract
The adiponectin receptors AdipoR1 and AdipoR2 have been identified to mediate the insulin-sensitizing effects of adiponectin. Although AdipoR2 was suggested to be the main receptor for this adipokine in hepatocytes, AdipoR1 protein is highly abundant in primary human hepatocytes and hepatocytic cell lines. Nuclear receptors are main regulators of lipid metabolism and activation of peroxisome proliferator-activated receptor alpha and gamma, retinoid X receptor (RXR), and liver X receptor (LXR) by specific ligands may influence AdipoR1 abundance. AdipoR1 protein is neither altered by RXR or LXR agonists nor by pioglitazone. In contrast, fenofibric acid reduces AdipoR1 whereas hepatotoxic troglitazone upregulates AdipoR1 protein in HepG2 cells. Taken together this work shows for the first time that AdipoR1 protein is expressed in human hepatocytes but that it is not a direct target gene of nuclear receptors. Elevated AdipoR1 induced by hepatotoxic troglitazone may indicate a role of this receptor in adiponectin-mediated beneficial effects in liver damage. (c) 2005 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY LIVER; ACTIVATION; ACID; TRANSCRIPTION; OBESITY; LEPTIN; GAMMA; MICE; adiponectin; 9-cis-retinoic acid; hepatocyte; 25-hydroxycholesterol; retinoid X receptor; liver X receptor; peroxisome proliferator-activated receptor gamma; AdipoR1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Apr 2021 07:54 |
| Last Modified: | 27 Apr 2021 07:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35628 |
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