Clinical strategy in hereditary hemorrhagic telangiectasia

Kuehnel, Thomas S. and Wagner, Birgit H. and Schurr, Christian P. and Strutz, Juergen (2005) Clinical strategy in hereditary hemorrhagic telangiectasia. AMERICAN JOURNAL OF RHINOLOGY, 19 (5). pp. 508-513. ISSN 1050-6586,

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Abstract

Background: Hereditary hemorrhagic telangiectasia (HHT) is a recurrent bleeding tendency caused by vascular malformations and preferentially involving the mucous membrane of the nose. The rhinological management of epistaxis is a challenge in which the frequency of bleeding has to be reduced without damage to the nasal mucosa, despite the fact that therapy necessarily has to be repeated. Methods: The clinical course in 30 patients with HHT was monitored prospectively. Nasal mucosal efflorescences underwent Nd:YAG laser therapy at individually defined intervals, and the effect on the frequency and duration of bleeding was documented, as were adverse effects. Results: No serious adverse effects (e.g., septal defects or synechiae) were observed as a consequence of therapy. During the course of laser therapy and ongoing compliance with nasal mucosal care instructions, the frequency of bleeding fell from "several times daily" to "every 2 weeks." Conclusion: In conjunction with Nd:YAG laser therapy, ongoing and consistent care of the nasal mucosa is a proven and effective treatment regimen in HHT As an integral element in an interdisciplinary strategy for diagnosis and therapy, this regimen yields satisfactory quality of life while avoiding local complications.

Item Type: Article
Uncontrolled Keywords: EPISTAXIS; LASER; MANAGEMENT; CHALLENGE;
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
Depositing User: Dr. Gernot Deinzer
Date Deposited: 27 Apr 2021 08:11
Last Modified: 27 Apr 2021 08:11
URI: https://pred.uni-regensburg.de/id/eprint/35636

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