May, F. and Vroemen, M. and Matiasek, K. and Henke, J. and Brill, T. and Lehmer, A. and Apprich, M. and Erhardt, W. and Schoeler, S. and Paul, R. and Blesch, A. and Hartung, R. and Gansbacher, B. and Weidner, N. (2005) Nerve replacement strategies for cavernous nerves. EUROPEAN UROLOGY, 48 (3). pp. 372-378. ISSN 0302-2838
Full text not available from this repository. (Request a copy)Abstract
Objective: This article reviews novel restorative therapies for cavernous nerves that may be used to replace resected cavernous nerves at the time of pelvic surgery. Methods: A literature-based presentation (Medline search) on current nerve replacement strategies was conducted with emphasis on neurobiological factors contributing to the restoration of erectile function after cavernous nerve injuries. Results: A promising alternative to autologous nerve grafts for extending the length of successful nerve regeneration are artificial nerve guides. The addition of neurotrophic factors, extracellular matrix components and Schwann cells has been shown to promote cavernous nerve regeneration. Neurotrophic factors can be incorporated in the scaffold or can be supplied by cells seeded into the stroma. The regenerative capacity of these cells can be further enhanced by genetic modification with neurotrophic factor encoding genes. Conclusions: Artificial nerve guides, especially biodegradable ones containing growth-promoting factors or cells, are a promising option for the repair of cavernous nerve lesions. (c) 2005 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESTORE ERECTILE FUNCTION; PERIPHERAL-NERVE; SCHWANN-CELLS; RADICAL PROSTATECTOMY; NEUROTROPHIC FACTOR; GROWTH-FACTOR; SPINAL-CORD; ADULT-RAT; AXONAL GROWTH; FOLLOW-UP; Schwann cells; nerve regeneration; erection; cavernous nerves; neurotrophic factors; nerve guides |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Jun 2022 10:27 |
| Last Modified: | 21 Jun 2022 10:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35683 |
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