Leroux-Roels, Geert and Marchant, Arnaud and Levy, Jack and Van Damme, Pierre and Schwarz, Tino F. and Horsmans, Yves and Jilg, Wolfgang and Kremsner, Peter G. and Haelterman, Edwige and Clement, Frederic and Gabor, Julian J. and Esen, Meral and Hens, Annick and Carletti, Isabelle and Fissette, Laurence and Da Silva, Fernanda Tavares and Burny, Wivine and Janssens, Michel and Moris, Philippe and Didierlaurent, Arnaud M. and Van der Most, Robbert and Garcon, Nathalie and Van Belle, Pascale and Van Mechelen, Marcelle (2016) Impact of adjuvants on CD4(+) T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial. CLINICAL IMMUNOLOGY, 169. pp. 16-27. ISSN 1521-6616, 1521-7035
Full text not available from this repository. (Request a copy)Abstract
Immunogenicity and safety of different adjuvants combined with a model antigen (HBsAg) were compared. Healthy HBV-naive adults were randomized to receive HBs adjuvanted with alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with frequencies significantly higher in the AS01B and AS01E groups than in the other groups. Antibody concentrations 30 days post-dose 2 were significantly higher in AS01B, AS01E and AS03A than in other groups. Limited correlations were observed between HBs-specific CD4+ T cell and antibody responses. Injection site pain was the most common solicited local symptom and was more frequent in AS groups than in alum group. Different adjuvants formulated with the same antigen induced different adaptive immune responses and reactogenicity patterns in healthy naive adults. (C) 2016 The Authors. Published by Elsevier Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PANDEMIC INFLUENZA VACCINE; CROSS-REACTIVE IMMUNITY; MONOPHOSPHORYL-LIPID-A; CIRCUMSPOROZOITE PROTEIN; FALCIPARUM-MALARIA; SURFACE-ANTIGEN; HERPES-ZOSTER; INDUCE STRONG; SYSTEM; SAFETY; Adaptive immune response; Adjuvant system; CD4(+) T cell; Hepatitis B virus surface antigen; Memory B cell; Polyfunctionality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2019 14:21 |
| Last Modified: | 08 Apr 2019 06:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3569 |
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