Weber, Frank and Hollnberger, Harald and Gruber, Michael and Frank, Bernhard and Taeger, Kai (2005) The correlation of the Narcotrend Index with endtidal sevoflurane concentrations and hemodynamic parameters in children. PEDIATRIC ANESTHESIA, 15 (9). pp. 727-732. ISSN 1155-5645,
Full text not available from this repository. (Request a copy)Abstract
Background: The Narcotrend Index (NI) of anesthetic depth is potentially a pharmacodynamic measure of the effects of sevoflurane on the brain. Methods: In this prospective observational study of 30 pediatric surgical patients (1-11 years), we investigated the correlation between nonsteady-state endtidal sevoflurane (eT(Sevo)), NI, mean arterial pressure (MAP), and heart rate (HR). The performance of the Narcotrend for differentiation between consciousness and unconsciousness was evaluated using prediction probability (P-K). Results: Spearman correlation analysis showed significant correlations (P < 0.01) between eT(Sevo) and NI (r = -0.85) and MAP (r = -0.43). P-K-values for differentiation between consciousness and unconsciousness were 1.0 for NI and < 0.85 for MAP and HR. During the surgical procedure, NI-values showed a constant rise with each 0.5% step of lowering eT(Sevo) (P < 0.03), whereas MAP remained unaltered and HR showed a constant decline (P < 0.03), except between 1.5 and 1%. Conclusions: In children, nonsteady-state eT(Sevo) concentrations are more closely related with NI than with MAP or HR. In this study, only NI reliably differentiated consciousness from unconsciousness.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BISPECTRAL INDEX; ANESTHETIC DEPTH; MONITOR; PERFORMANCE; ALGORITHMS; BIS; narcotrend; children; sevoflurane |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Apr 2021 13:31 |
| Last Modified: | 30 Apr 2021 13:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35724 |
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