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Full text not available from this repository. (Request a copy)Abstract
Bladder cancer is a frequent disease and represents the second most common genitourinary neoplasm. Although many aspects of the management of superficial bladder cancer are now well established, significant challenges remain, which influences patient outcome. Early detection and treatment of recurrent disease is required to optimize bladder preservation, reduce patient morbidity, and increase quality of life and survival. Fluorescence endoscopy, often referred to as 'photodynamic diagnosis' (PDD), with intravesical application of photosensitizing agents, has been developed to enhance the early detection of bladder cancer. There is growing evidence that PDD using 5-aminolaevulinic acid (ALA), hexyl-ALA ester or hypericin enhances the detection of bladder cancer, particularly of high-grade flat lesions. Furthermore, transurethral resection of bladder tumour under fluorescence guidance reduces the risk of recurrent tumours. However, the impact on the progression of disease remains unclear and must be investigated in prospective randomized trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; 5-AMINOLEVULINIC ACID; PROTOPORPHYRIN-IX; TRANSURETHRAL RESECTION; IN-SITU; PORPHOBILINOGEN DEAMINASE; INTRAVESICAL INSTILLATION; CANCER; HYPERICIN; STATE; bladder carcinoma; urothelial carcinoma; PDD; fluorescence endoscopy; endoscopy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 04:43 |
| Last Modified: | 03 May 2021 04:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35786 |
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