Witzgall, Ralph (2005) New developments in the field of cystic kidney diseases. CURRENT MOLECULAR MEDICINE, 5 (5). pp. 455-465. ISSN 1566-5240, 1875-5666
Full text not available from this repository. (Request a copy)Abstract
For quite some time the field of polycystic kidney disease has led a life at the fringe of kidney research, but with the cloning of the PKD1 and many other genes this situation has dramatically changed. Polycystic kidney disease often is a syndromic disease affecting a variety of organs in addition to the kidney. Most of the proteins involved in polycystic kidney disease have been localized to the primary cilium, an extension at the apical membrane of renal tubular epithelial cells, which may serve chemo- and mechanosensory functions. It is speculated that primary cilia and their associated proteins play a role in determining the proper tubular geometry.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BARDET-BIEDL-SYNDROME; SEA-URCHIN SPERM; RIGHT AXIS DETERMINATION; HUMAN OBESITY SYNDROME; LEFT-RIGHT ASYMMETRY; PRIMARY CILIA; CATION CHANNEL; PLASMA-MEMBRANE; PKD1 GENE; EPITHELIAL-CELLS |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Ralph Witzgall |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Jun 2022 05:52 |
| Last Modified: | 21 Jun 2022 05:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35793 |
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