Fisher, Sheila A. and Abecasis, G. R. and Yashar, B. M. and Zareparsi, S. and Swaroop, A. and Iyengar, S.K. and Klein, B. E. K. and Klein, R. and Lee, K. E. and Majewski, J. and Schultz, D. W. and Klein, M. L. and Seddon, J. M. and Santangelo, S. L. and Weeks, D. E. and Conley, Y. P. and Mah, T. S. and Schmidt, S. and Haines, J. L. and Pericak-Vance, M. A. and Gorin, M. B. and Schulz, H. L. and Pardi, F. and Lewis, C. M. and Weber, Bernhard H. F. (2005) Meta-analysis of genome scans of age-related macular degeneration. HUMAN MOLECULAR GENETICS, 14 (15). pp. 2257-2264. ISSN 0964-6906,
Full text not available from this repository. (Request a copy)Abstract
A genetic contribution to the development of age-related macular degeneration (AMD) is well established. Several genome-wide linkage studies have identified a number of putative susceptibility loci for AMD but only a few of these regions have been replicated in independent studies. Here, we perform a meta-analysis of six AMD genome screens using the genome-scan meta-analysis method, which allows linkage results from several studies to be combined, providing greater power to identify regions that show only weak evidence for linkage in individual studies. Results from non-parametric analysis for a broad AMD clinical phenotype (including two studies with quantitative traits) were extracted. For each study, 120 genomic bins of similar to 30 cM were defined and ranked according to maximum evidence for linkage within each bin. Bin ranks were weighted according to study size and summed across all studies; the summed rank (SR) for each bin was assessed empirically for significance using permutation methods. A high SR indicates a region with consistent evidence for linkage across studies. The strongest evidence for an AMD susceptibility locus was found on chromosome 10q26 where genome-wide significant linkage was observed (P=0.00025). Several other regions met the empirical significance criteria for bins likely to contain linked loci including adjacent pairs of bins on chromosomes 1q, 2p, 3p and 16. Several of the regions identified here showed only weak evidence for linkage in the individual studies. These results will help prioritize regions for future positional and functional candidate gene studies in AMD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BEAVER DAM EYE; STARGARDT-DISEASE GENE; COMPLEX HUMAN-DISEASES; SUSCEPTIBILITY LOCI; FAMILIAL AGGREGATION; LINKAGE ANALYSIS; EXTENDED FAMILIES; BIPOLAR DISORDER; OXIDATIVE STRESS; APOLIPOPROTEIN-E; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 06:46 |
| Last Modified: | 03 May 2021 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35803 |
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