Wild, Peter J. and Kunz-Schughart, Leoni A. and Stoehr, Robert and Burger, Maximilian and Blaszyk, Hagen and Simon, Ronald and Gasser, Thomas and Mihatsch, Michael and Sauter, Guido and Hartmann, Arndt (2005) High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer. INTERNATIONAL JOURNAL OF ONCOLOGY, 27 (2). pp. 385-391. ISSN 1019-6439, 1791-2423
Full text not available from this repository. (Request a copy)Abstract
To investigate whether protein expression of cyclooxygenase 2 (COX2) is associated with tumor phenotype, immunohistochemical alterations, and clinical outcome in urinary bladder cancer (BC). Tissue microarrays (n=776) were used to analyze COX2, P53 and the Ki-67 labeling index immunohistochemically. A monoclonal mouse antibody was used after heat-induced antigen retrieval. COX2 expression was scored semiquantitatively (0-3+). COX2 expression was detected in 60% (368/617) of urothelial BC. Positive COX2 staining, was seen in 77.8% (140/182) of muscle invasive urothelial BC, compared to 35% (7/20) of muscle invasive squamous cell carcinomas (p < 0.001). COX2 protein expression was associated with advanced tumor stage (p < 0.0001), high-grade histology (p < 0.0001), solid growth pattern in invasive BC (pT1-4: p=0.02) high Ki-67 labeling index (p < 0.0001), and positive P53 IHC (p < 0.001). COX2 expression was not associated with survival, recurrence, and progression in clinically relevant subgroups (pTa, pT1, pT2-4). Expression of COX2 is common in advanced BC with poor prognostic characteristics, supporting efforts to initiate clinical trials on the efficacy of COX2 inhibitors in the adjuvant treatment of high-risk urinary BC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; CYCLOOXYGENASE-2 EXPRESSION; INHIBITION; ASPIRIN; MARKERS; GRADE; RISK; bladder neoplasms; immunohistochemistry; prosta-glandin-endoperoxide synthase |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 07:14 |
| Last Modified: | 03 May 2021 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35812 |
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