Schneider, Armin and Krueger, C. and Steigleder, T. and Weber, D. and Pitzer, C. and Laage, R. and Aronowski, J. and Maurer, M. H. and Gassler, N. and Mier, W. and Hasselblatt, M. and Kollmar, R. and Schwab, S. and Sommer, C. and Bach, A. and Kuhn, Hans-Georg and Schaebitz, Wolf-Ruediger (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. JOURNAL OF CLINICAL INVESTIGATION, 115 (8). pp. 2083-2098. ISSN 0021-9738, 1558-8238
Full text not available from this repository. (Request a copy)Abstract
G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation of neutrophilic granulocytes. Here, we show that G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke. G-CSF displays strong antiapoptotic activity in mature neurons and activates multiple cell survival pathways. Both G-CSF and its receptor are widely expressed by neurons in the CNS, and their expression is induced by ischemia, which suggests an autocrine protective signaling mechanism. Surprisingly, the G-CSF receptor was also expressed by adult neural stem cells, and G-CSF induced neuronal differentiation in vitro. G-CSF markedly improved long-term behavioral outcome after cortical ischemia, while stimulating neural progenitor response in vivo, providing a link to functional recovery. Thus, G-CSF is an endogenous ligand in the CNS that has a dual activity beneficial both in counteracting acute neuronal degeneration and contributing to long-term plasticity after cerebral ischemia. We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; FOCAL CEREBRAL-ISCHEMIA; TRANSIENT GLOBAL-ISCHEMIA; ENDOTHELIAL GROWTH-FACTOR; NEWLY GENERATED NEURONS; CENTRAL-NERVOUS-SYSTEM; LONG-TERM SURVIVAL; NEURAL STEM-CELLS; RAT DENTATE GYRUS; HIPPOCAMPAL-NEURONS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 08:15 |
| Last Modified: | 03 May 2021 08:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35817 |
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