Hillebrandt, S. and Wasmuth, H. E. and Weiskirchen, R. and Hellerbrand, Claus and Keppeler, H. and Werth, A. and Schirin-Sokhan, R. and Wilkens, G. and Geier, A. and Lorenzen, J. and Kohl, J. and Gressner, A. M. and Matern, S. and Lammert, Frank (2005) Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. NATURE GENETICS, 37 (8). pp. 835-843. ISSN 1061-4036, 1546-1718
Full text not available from this repository. (Request a copy)Abstract
Fibrogenesis or scarring of the liver is a common consequence of all chronic liver diseases. Here we refine a quantitative trait locus that confers susceptibility to hepatic fibrosis by in silico mapping and show, using congenic mice and transgenesis with recombined artificial chromosomes, that the gene Hc (encoding complement factor C5) underlies this locus. Small molecule inhibitors of the C5a receptor had antifibrotic effects in vivo, and common haplotype-tagging polymorphisms of the human gene C5 were associated with advanced fibrosis in chronic hepatitis C virus infection. Thus, the mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC HEPATITIS-C; FIBROSIS PROGRESSION; C5A; RECEPTOR; EXPRESSION; RESPONSES; REGENERATION; ANTAGONISTS; COMPONENT; GENOTYPES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 11:43 |
| Last Modified: | 03 May 2021 11:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35838 |
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