Biebl, Manfred and Winner, Beate and Winkler, Juergen (2005) Caspase inhibition decreases cell death in regions of adult neurogenesis. NEUROREPORT, 16 (11). pp. 1147-1150. ISSN 0959-4965, 1473-558X
Full text not available from this repository. (Request a copy)Abstract
The generation of new neurons in adult neurogenic regions is paralleled by a high rate of cell death. To further characterize the interplay between generation and removal of new cells, we studied the role of caspase 2 (Nedd 2) and 3 (CPP 32) on the basis of the high expression of these cysteine proteases in neurogenic regions. By injecting the broad spectrum caspase inhibitor BOC-Asp(OMe)-fluoromethyl ketone into the lateral ventricle of adult rats, a 60% reduction of terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) profiles was observed in all neurogenic regions without changing the number of newly generated cells. These data suggest that inhibiting the caspase activity in vivo decreases the rate of cell death, but has no influence on the generation of new neurons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RAT OLFACTORY-BULB; GRANULE NEURONS; DENTATE GYRUS; NERVOUS-SYSTEM; BRAIN; APOPTOSIS; PROLIFERATION; DOUBLECORTIN; HIPPOCAMPUS; FOREBRAIN; adult neurogenesis; apoptosis; bromodeoxyuridine; caspase; olfactory bulb; progenitor cell; proliferation; stem; subventricular zone |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2021 11:52 |
| Last Modified: | 03 May 2021 11:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35841 |
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