Salmen, Sunnhild and Hoechstetter, Julia and Kaesbauer, Christian and Paper, Dieter H. and Bernhardt, Guenther and Buschauer, Armin (2005) Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae. PLANTA MEDICA, 71 (8). pp. 727-732. ISSN 0032-0943, 1439-0221
Full text not available from this repository. (Request a copy)Abstract
Potent and specific inhibitors of hyaluronidases, a group of enzymes preferentially catalysing the hydrolysis of hyaluronic acid, are not known so far. Such compounds could be useful as pharmacological tools for studying the physiological and pathophysiological role of both hyaluronan and hyaluronidases. The effects of sulphated and non-sulphated structurally different oligosaccharides on bovine testicular hyaluronidase, hyaluronidase from bee venom and hyaluronate lyase from Streptococcus agalactiae (hylB(4755)) were studied with the Morgan-Elson reaction. Several active compounds were identified within a series of sulphated beta-(1,4)-galacto-oligosaccharides. The determined IC50 values of these sulphated oligosaccharides ranged from 4 mu M to 630 mu M for all hyaluronan-degrading enzymes. Sulphated oligosaccharides like verbascose, planteose and neomycin showed comparable inhibition on all hyaluronidases, thereby possessing 100-500 times the activity of the widely accepted hyaluronidase inhibitor apigenin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYALURONATE LYASE; FLAVONOIDS; CELLS; ACID; bovine testicular hyaluronidase; hyaluronate lyase; bee venom hyaluronidase; hyaluronic acid; sulphated oligosaccharide; inhibitors |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 May 2021 05:56 |
| Last Modified: | 04 May 2021 05:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35854 |
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