Reich, G. and Cornely, O. A. and Sandherr, M. and Kubin, T. and Krause, Stefan and Einsele, H. and Thiel, E. and Bellaire, T. and Dorken, B. and Maschmeyer, Georg (2005) Empirical antimicrobial monotherapy in patients after high-dose chemotherapy and autologous stem cell transplantation: a randomised, multicentre trial. BRITISH JOURNAL OF HAEMATOLOGY, 130 (2). pp. 265-270. ISSN 0007-1048, 1365-2141
Full text not available from this repository. (Request a copy)Abstract
We report on 232 patients undergoing autologous haematopoietic stem cell transplantation (ASCT) entered into a multicentre, randomised trial comparing the efficacy and tolerability of meropenem (MPM) with that of piperacillin/tazobactam (P/T) as empirical antimicrobial first-line therapy for febrile neutropenia. In 27.6% of patients in the MPM group and 22.4% in the P/T group, therapy was initially supplemented with a glycopeptide for venous catheter infection or bacteraemia because of coagulase-negative staphylococci. Complete response rate after 72 h was 63.8% in the MPM group and 49.6% in the P/T group (P = 0.034). Overall complete response rate after treatment modification was 94.0% in the MPM group and 93.1% in the P/T group. Median time to defervescence was 2 d in the MPM group and 3 d in the P/T group. The most frequently isolated pathogens were Gram-positive cocci. Treatment was well tolerated in both groups. One patient (0.4%) died from infection. Empirical first-line therapy with MPM as well as with P/T is safe and effective in febrile episodes emerging after ASCT. Higher response rates to primary treatment can be achieved with MPM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EARLY INFECTIOUS COMPLICATIONS; FEBRILE NEUTROPENIC PATIENTS; CEFTAZIDIME PLUS AMIKACIN; COMBINATION THERAPY; MULTIPLE-MYELOMA; CANCER-PATIENTS; DOUBLE-BLIND; MEROPENEM; FEVER; LYMPHOMA; autologous stem cell transplantation; febrile neutropenia; meropenem; piperacillin; tazobactam; monotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2021 05:01 |
| Last Modified: | 07 May 2021 05:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35905 |
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