Bollheimer, L. Cornelius and Buettner, Roland and Kullmann, Anja and Kullmann, Frank (2005) Folate and its preventive potential in colorectal carcinogenesis. How strong is the biological and epidemiological evidence? CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 55 (1). pp. 13-36. ISSN 1040-8428, 1879-0461
Full text not available from this repository. (Request a copy)Abstract
Based on a 15-year old hypothesis, it is believed that an adequate ingestion of folate vitamins decreases, whereas a nutritional depletion of folate increases the risk of colorectal cancer. The present article reviews the efforts to provide biochemical and epidemiological evidence for folate as a chemopreventive agent against colorectal carcinogenesis. Biological evidence: Tetrahydrofolates govern the intracellular one-carbon metabolism and account for proper DNA biosynthesis and macro-molecular modification. Numerous experimental studies traced different molecular pathways and tried to link folate depletion with DNA instability and/or mutagenesis. However, none of the proposed underlying molecular mechanisms appear clearly defined. Epidemiological evidence: Numerous case-control and prospective studies have been conducted on folate and colorectal cancer, which all together miss a clinical bottom line. The recommendation of folate intake to prevent colorectal cancer is therefore not evidence-based. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEURAL-TUBE DEFECTS; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM; ADENOMA-CARCINOMA SEQUENCE; HAMSTER OVARY CELLS; FOLIC-ACID SUPPLEMENTATION; CHRONIC ULCERATIVE-COLITIS; ABERRANT CRYPT FORMATION; GENOMIC DNA METHYLATION; TUMOR-SUPPRESSOR GENE; ONE-CARBON METABOLISM; folic acid; folate; MTHFR polymorphism; DNA methylation; colorectal carcinogenesis; prevention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Mar 2022 08:04 |
| Last Modified: | 23 Mar 2022 08:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35912 |
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