Sachs, Helmut G. and Gekeler, F. and Schwahn, H. and Jakob, W. and Koehler, M. and Schulmeyer, Frank and Marienhagen, Joerg and Brunner, U. and Framme, Carsten (2005) Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 15 (4). pp. 493-499. ISSN 1120-6721,
Full text not available from this repository. (Request a copy)Abstract
PURPOSE. During the course of the development of visual prostheses, subretinal stimulation films were implanted in micropigs in order to prove the feasibility of subretinal electrical stimulation with subsequent cortical response. One aim was to demonstrate that epidural recording of visual evoked potentials is possible in the micropig. METHODS. Film-bound stimulation electrode arrays were placed in the subretinal space of micropigs. This enabled the retina to be stimulated subretinally. Since conventional visual evoked potential (VEP) measuring is virtually impossible in the pig from the neurosurgical point of view, epidural recording electrode arrays were positioned over the visual cortex as permanent electrodes. RESULTS. The feasibility of temporary implantation of film-bound stimulation electrode arrays was successfully demonstrated in the micropig model. On stimulation with monopolar voltage pulses (1000 to 3000 mV), reproducible epidural VEP measurements (5 to 10 mu V) were detected. CONCLUSIONS. The feasibility of subretinal stimulation of the retina was demonstrated in a retinal model that is similar to the human retina. This animal model therefore offers a suitable means of studying the tolerability of stimulation situations in the course of visual prosthesis development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARRAY RETINAL PROSTHESIS; ELECTRICAL-STIMULATION; MICROPHOTODIODE ARRAY; RABBIT RETINA; BLIND; animal model; retinal implant; visual prosthesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Neurochirurgie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2021 06:09 |
| Last Modified: | 07 May 2021 06:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35917 |
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