Thasler, Wolfgang E. and Schlott, T. and Thelen, P. and Hellerbrand, Claus and Bataille, Frauke and Lichtenauer, M. and Schlitt, Hans Juergen and Jauch, K. W. and Weiss, Thomas S. (2005) Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma. HISTOPATHOLOGY, 47 (1). pp. 57-66. ISSN 0309-0167, 1365-2559
Full text not available from this repository. (Request a copy)Abstract
Aims: To determine the expression of a protein termed augmenter of liver regeneration (ALR), recently found to have a specific and beneficial effect on the process of liver regeneration in normal and diseased human liver. Methods and results: ALR expression in normal and cirrhotic human livers with various underlying diseases as well as in tissue samples of hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCC) was analysed by immunohistochemistry and quantitative reverse transciptase-polymerase chain reaction (RT-PCR). Expression analysis of ALR in total liver protein extracts by Western blotting showed mainly dimeric ALR protein. Immunohistochemically, cytosolic and perinuclear immunosignals were found in hepatocytes and cholangiocytes in normal, cirrhotic or cancerous liver tissue and only weak signals in some endothelial cells in normal livers. Quantitative mRNA analysis revealed significantly increased ALR expression in cirrhosis compared with normal liver tissue. In HCC and CCC ALR mRNA expression was also significantly enhanced compared with normal liver tissue, but expression levels did not differ from the matching non-neoplastic tissue in the same patient. Conclusions: The findings suggest an important role for ALR in hepatocellular regeneration in liver cirrhosis as well as in hepatocarcinogenesis and therefore its potential value in the clinical diagnosis of hepatic cirrhosis and cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATOCYTE GROWTH-FACTOR; HEPATIC STIMULATOR SUBSTANCE; HUMAN HEPATOCELLULAR-CARCINOMA; RECEPTOR C-MET; SULFHYDRYL OXIDASE; MESSENGER-RNA; FACTOR-ALPHA; GENE; YEAST; HEPATOPOIETIN; augmenter of liver regeneration; immunohistochemistry; liver carcinoma; liver cirrhosis; real-time RT-PCR |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2021 07:01 |
| Last Modified: | 07 May 2021 07:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35934 |
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