Barlage, Stefan and Hauser, I. A. and Elbracht, R. and Abletshauser, C. and Schmieder, R. E. and Weidinger, G. and Lackner, K. J. and Rothe, G. and Schmitz, Gerd (2005) Monitoring of peripheral blood cytotoxic T-cells under fluvastatin treatment in renal transplant recipients. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 19 (3-4). pp. 159-168. ISSN 0393-974X,
Full text not available from this repository.Abstract
Flow cytometric T-cell analysis is capable of adding valuable information for balancing immunosuppression in transplant recipients as it can take into account individual effects of immunosuppressive drugs on each patient as well as effects of other drugs which may modify the overall immunosuppression. Studies suggest that HMG-CoA-reductase-inhibitors (statins) reduce the frequency of organ rejection, although the precise mechanism of this effect is unknown. We therefore evaluated the effect of fluvastatin on size and activation of T-cell subpopulations and NK-cell activity in renal transplant recipients. At baseline, the population size of activated (HLA-DR+) T-cells was negatively correlated to serum HDL cholesterol suggesting an increased T-cell activation at low HDL levels. Fluvastatin treatment of a hypercholesterolemic group of patients for two months significantly decreased the LDL cholesterol. A longitudinal analysis revealed a relative increase in non-MHC restricted cytotoxic T-cells (CD3(+)/CD16(+) or CD56(+)) over time which was significantly attenuated in fluvastatin treated patients but not in normocholesterolemic controls. Moreover, a relative decrease of activated MHC class T-restricted cytotoxic CD8(+) T-cells was only observed upon fluvastatin treatment. NK-cell number and activity did not differ between groups. In summary, fluvastatin treatment of hypercholesterolemic renal transplant recipients is associated with a specific modulation of T-cells exerting cytotoxic effector functions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; KIDNEY-TRANSPLANTATION; MEDIATED CYTOTOXICITY; STEROL SYNTHESIS; ACUTE REJECTION; PRAVASTATIN; CYCLOSPORINE; LYMPHOCYTES; MECHANISMS; LOVASTATIN; flow cytometry; cytotoxic T-cells; HMG-CoA reductase inhibitor; statin; transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2021 10:04 |
| Last Modified: | 07 May 2021 10:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35943 |
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