Song, In-Ho and Gold, Ralf and Straub, Rainer H. and Burmester, Gerd-Rüdiger and Buttgereit, Frank (2005) New glucocorticoids on the horizon: Repress, don't activate! JOURNAL OF RHEUMATOLOGY, 32 (7). pp. 1199-1207. ISSN 0315-162X, 1499-2752
Full text not available from this repository. (Request a copy)Abstract
Glucocorticoids are highly effective drugs; their immunosuppressive and antiinflammatory actions are used in the treatment of many rheumatic and other inflammatory diseases. However, their use is sometimes considerably limited by numerous adverse reactions. For this reason, great efforts have been made in recent years to develop innovative glucocorticoids or glucocorticoid receptor ligands that have improved therapeutic effect/adverse reaction ratio. We summarize the position and critically discuss the following products that are currently under development: (1) selective glucocorticoid receptor agonists (SEGRA or dissociating glucocorticoids); (2) nitrosteroids; and (3) long-circulating liposomal glucocorticoids. Finally, we describe the state of research on membrane-bound glucocorticoid receptors as possible further targets for specific glucocorticoid actions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; STERICALLY STABILIZED LIPOSOMES; LONG-CIRCULATING LIPOSOMES; NITRIC-OXIDE SYNTHASE; RHEUMATOID-ARTHRITIS; MOLECULAR-MECHANISMS; DNA-BINDING; ANTIINFLAMMATORY ACTIONS; SCINTIGRAPHIC DETECTION; THERAPEUTIC BENEFIT; glucocorticoids; genomic and nongenomic mechanisms; cytosolic and membrane-bound glucocorticoid receptor; transactivation; transrepression; nitric oxide |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2021 11:48 |
| Last Modified: | 07 May 2021 11:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35950 |
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