Haen, Ekkehard (2005) Relevance of clinical pharmacological comments in TDM. PSYCHOPHARMAKOTHERAPIE, 12 (4). pp. 138-143. ISSN 0944-6877,
Full text not available from this repository. (Request a copy)Abstract
Pure laboratory data are often misinterpreted, because the "normal range" given does not meet individual needs. We offer clinical pharmacological comments that interprete laboratory results in relation to both, a reference range and the individual dose. Deviations are explained as compliance problems, interactions with food and drugs or the individual's metabolic state. The paper presents as an example our clinical pharmacological comments for 225 specimens of olanzapine analysed between January 7 and May 14, 2002. We calculated concentrations that were expected for a given dose. Some 46% of the determinations revealed deviations from these reference Values, even if the concentration itself was within the "normal range" used in the laboratory, which held true for about half of these values. One third of these values were "relatively low" which could be attributed to the patients' smoking. The rest was classified "relatively high" which could be attributed to drug-drug interactions such as 2D6-inhibition by metoprolol and timolol or that remained unexplained being suspect of a poor metabolizer state. Comments given by clinical pharmacologists to determinations of drug concentrations in TDM were accepted very controversially by clinicians. Clinicians often felt supervised or patronised by such comments. In particular young physicians, however, estimated the clinical pharmacological commenting whereas experienced clinical specialists felt they knew their patients better than the clinical pharmacologist.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OLANZAPINE; therapeutic drug monitoring (TDM); clinical pharmacological comment; olanzapine; drug interactions; therapeutic range |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 07:00 |
| Last Modified: | 10 May 2021 07:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35975 |
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