Nerve repair strategies for restoration of erectile function after radical pelvic surgery

May, F. and Schoeler, S. and Vroemen, Maurice and Matiasek, K. and Apprich, M. and Erhardt, W. and Hartung, R. and Gansbacher, B. and Weidner, Norbert (2005) Nerve repair strategies for restoration of erectile function after radical pelvic surgery. UROLOGE, 44 (7). pp. 780-784. ISSN 1433-0563,

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Abstract

latrogenic cavernous nerve lesions occurring during radical pelvic surgery often lead to irreversible erectile dysfunction. The nerve defects after excision of the neurovascular bundles must be reconstructed by interposition grafting to supply a permissive scaffold for oriented axonal regrowth. The use of autologous nerve grafts for the repair of human cavernous nerves during radical prostatectomy has been controversial regarding the limited success achieved with bilateral nerve grafting. Artificial nerve guides consisting of natural or synthetic materials have been successfully used for bridging peripheral nerve defects. The combination with Schwann cells, neurotrophic factors and extracellular matrix components has been shown to promote cavernous nerve regeneration.

Item Type: Article
Uncontrolled Keywords: PERIPHERAL-NERVE; SCHWANN-CELLS; RETROPUBIC PROSTATECTOMY; FOLLOW-UP; REGENERATION; GRAFTS; DYSFUNCTION; TUBES; MEN; erectile nerves; prostatectomy; interposition grafting; nerve guides; Schwann cells
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Neurologie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 10 May 2021 07:56
Last Modified: 10 May 2021 07:56
URI: https://pred.uni-regensburg.de/id/eprint/35982

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