Wild, Peter J. and Herr, A. and Wissmann, C. and Stoehr, Robert and Rosenthal, A. and Zaak, D. and Simon, R. and Knuechel, R. and Pilarsky, C. and Hartmann, Arndt (2005) Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladder. CLINICAL CANCER RESEARCH, 11 (12). pp. 4415-4429. ISSN 1078-0432, 1557-3265
Full text not available from this repository. (Request a copy)Abstract
Purpose:The aim of the present study was to define gene expression profiles of noninvasive and invasive bladder cancer, to identify potential therapeutic or screening targets in bladder cancer, and to define genetic changes relevant for tumor progression of recurrent papillary bladder cancer (pTa). Experimental Design: Overall, 67 bladder neoplasms (46 pTa, 3 pTis, 10 pT1, and 8 pT2) and eight normal bladder specimens were investigated by a combination of laser microdissection and gene expression profiling. Eight of 16 patients with recurrent noninvasive papillary bladder tumors developed carcinoma in situ (pTis) or invasive bladder cancer (>= pT1G2) in the course of time. RNA expression results of the putative progression marker cathepsin E (CTSE) were confirmed by immunohistochemistry using high-throughput tissue microarray analysis (n = 776). Univariate analysis of factors regarding overall survival, progression-free survival, and recurrence-free survival in patients with urothelial bladder cancer was done. Results: Hierarchical cluster analyses revealed no differences between pTaG1 and pTaG2 tumors. However, distinct groups of invasive cancers with different gene expression profiles in papillary and solid tumors were found. Progression-associated gene profiles could be defined (e.g., FABP4 and CTSE) and were already present in the preceding noninvasive papillary tumors. CTSE expression (P = 0.003) and a high Ki-67 labeling index of at least 5% (P = 0.01) were the only factors that correlated significantly with progression-free survival of pTa tumors in our gene expression approach. Conclusions: Gene expression profiling revealed novel genes with potential clinical utility to select patients that are more likely to develop aggressive disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMAS; PROLIFERATOR-ACTIVATED RECEPTORS; GROWTH-FACTOR RECEPTOR-3; ACID-BINDING PROTEIN; CATHEPSIN-E; IMMUNOHISTOCHEMICAL LOCALIZATION; MOLECULAR CLASSIFICATION; CANCER PROGRESSION; CDNA MICROARRAYS; TUMORS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 08:23 |
| Last Modified: | 10 May 2021 08:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35996 |
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