Knoell, Antje and Pietrzyk, Miriam and Loss, Martin and Goetz, Wolfgang A. and Jilg, Wolfgang (2005) Solid-organ transplantation in HBsAg-negative patients with antibodies to HBV core antigen: Low risk of HBV reactivation. TRANSPLANTATION, 79 (11). pp. 1631-1633. ISSN 0041-1337, 1534-6080
Full text not available from this repository. (Request a copy)Abstract
Hepatitis B virus (HBV) reactivation is a well-described event in HBV surface antigen (HbsAg)-positive patients undergoing immunosuppression. There are only few data about the risk of HBV reactivation in HBsAg-negative solid-organ transplant recipients with resolved HBV infection. We conducted a systematic screening of serum and liver samples from 38 HBsAg-negative and anti-HBV core antigen (anti-HBc) -positive patients for the presence of HBV-DNA and for serologic HBV markers before and after solid-organ transplantation (kidney, n=23; liver, n=9; heart, n=6). Pretransplant prevalence of HBV-DNA was 24% (6/25) in serum and 33% (3/9) in liver samples. Forty-four percent (15/34) of the recipients were viremic after transplantation; this finding was more common in patients coinfected with hepatitis C (P=0.011) and in patients negative for anti-HBs (P=0.001). Two recipients became antigenemic (H BsAg-positive), but none developed clinical signs of hepatitis. In conclusion, subclinical reactivation of HBV infection was detected in a significant proportion of HBsAg-negative solid-organ-transplant recipients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATITIS-B-VIRUS; ACUTE VIRAL-HEPATITIS; INFECTION; RECIPIENTS; RECOVERY; OCCULT; DNA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 May 2021 08:35 |
| Last Modified: | 10 May 2021 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/36000 |
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